8DSC

Human NAMPT in complex with substrate NAM and small molecule activator NP-A1-R

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Nicotinamide phosphoribosyltransferase	polymer	499	56666.1	2	UniProt (P43490) Pfam (PF18127) Pfam (PF04095) In PDB	Homo sapiens (human)	NAmPRTase,Nampt,Pre-B-cell colony-enhancing factor 1,Pre-B cell-enhancing factor,Visfatin
2	A, B	NICOTINAMIDE	non-polymer		122.1	2	Chemie (NCA)
3	A, B	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)
4	A, B	(3R)-1-[2-(4-methylphenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-yl]-N-{[4-(methylsulfanyl)phenyl]methyl}piperidine-3-carboxamide	non-polymer		472.6	2	Chemie (TIE)
5	A, B	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
6	A	CHLORIDE ION	non-polymer		35.5	3	Chemie (CL)
7	B	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
8		water	water		18.0	1038	Chemie (HOH)

Sequence modifications

A, B: 1 - 491 (UniProt: P43490)

PDB	External Database	Details
Leu 492	-	expression tag
Glu 493	-	expression tag
His 494	-	expression tag
His 495	-	expression tag
His 496	-	expression tag
His 497	-	expression tag
His 498	-	expression tag
His 499	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	113332.2
Non-Polymers*	Number of molecules	13
	Total formula weight	1785.0
All*	Total formula weight	115117.2

*Water molecules are not included.