8DS0
Product structure of SARS-CoV-2 Mpro C145A mutant in complex with nsp14-nsp15 (C14) cut site sequence (form 2)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | 3C-like proteinase nsp5 | polymer | 306 | 33921.7 | 2 | UniProt (P0DTD1) Pfam (PF05409) In PDB | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2) | 3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase |
2 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
3 | water | water | 18.0 | 115 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 300 (UniProt: P0DTD1)
PDB | External Database | Details |
---|---|---|
Ala 145 | Cys 3408 | engineered mutation |
Thr 301 | - | expression tag |
Phe 302 | - | expression tag |
Thr 303 | - | expression tag |
Arg 304 | - | expression tag |
Leu 305 | - | expression tag |
Gln 306 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 67843.4 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 106.1 | |
All* | Total formula weight | 67949.5 |