8DS0
Product structure of SARS-CoV-2 Mpro C145A mutant in complex with nsp14-nsp15 (C14) cut site sequence (form 2)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | 3C-like proteinase nsp5 | polymer | 306 | 33921.7 | 2 | UniProt (P0DTD1) Pfam (PF05409) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2) | 3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase |
| 2 | C (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 115 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 300 (UniProt: P0DTD1)
| PDB | External Database | Details |
|---|---|---|
| Ala 145 | Cys 3408 | engineered mutation |
| Thr 301 | - | expression tag |
| Phe 302 | - | expression tag |
| Thr 303 | - | expression tag |
| Arg 304 | - | expression tag |
| Leu 305 | - | expression tag |
| Gln 306 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 67843.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 106.1 | |
| All* | Total formula weight | 67949.5 |
