8DRU
Product structure of SARS-CoV-2 Mpro C145A mutant in complex with nsp7-nsp8 (C7) cut site sequence
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Fusion protein of 3C-like proteinase nsp5 and nsp7-nsp8 (C7) cut site | polymer | 306 | 33858.6 | 7 | UniProt (P0DTD1) Pfam (PF05409) | Severe acute respiratory syndrome coronavirus 2 | 3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase,nsp7 |
| 2 | CA, H, M, N, Q... (G, A, B, C, D...) | PHOSPHATE ION | non-polymer | 95.0 | 8 | Chemie (PO4) | |||
| 3 | AA, BA, DA, I, J... (F, G, A, B, C...) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 14 | Chemie (PEG) | |||
| 4 | EA, Y (G, E) | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 2 | Chemie (1PE) | |||
| 5 | FA, GA, HA, IA, JA... (A, B, C, D, E...) | water | water | 18.0 | 205 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G: 1 - 300 (UniProt: P0DTD1)
A, B, C, D, E, F, G: 301 - 306 (UniProt: P0DTD1)
| PDB | External Database | Details |
|---|---|---|
| Ala 145 | Cys 3408 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 237010.1 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 2722.0 | |
| All* | Total formula weight | 239732.1 |
