8DNZ
Cryo-EM structure of the human Sec61 complex inhibited by apratoxin F
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B | Protein transport protein Sec61 subunit gamma | polymer | 68 | 7752.3 | 1 | UniProt (P60059) Pfam (PF00584) In PDB | Homo sapiens (human) | |
2 | C | Protein transport protein Sec61 subunit beta | polymer | 96 | 9987.5 | 1 | UniProt (P60468) Pfam (PF03911) In PDB | Homo sapiens (human) | |
3 | A | Protein transport protein Sec61 subunit alpha isoform 1 | polymer | 476 | 52202.4 | 1 | UniProt (P61619) Pfam (PF10559) Pfam (PF00344) In PDB | Homo sapiens (human) | Sec61 alpha-1 |
4 | D | Apratoxin F peptide inhibitor | polymer | 5 | 848.1 | 1 | Lyngbya bouillonii |
Sequence modifications
A: 1 - 476 (UniProt: P61619)
PDB | External Database | Details |
---|---|---|
Tyr 263 | Val 263 | conflict |
Glu 264 | Asp 264 | engineered mutation |
Arg 268 | Lys 268 | engineered mutation |
Thr 270 | Ala 270 | engineered mutation |
Lys 271 | Arg 271 | engineered mutation |
Val 272 | Tyr 272 | engineered mutation |
Ile 276 | Tyr 276 | engineered mutation |
Gly 277 | Asn 277 | engineered mutation |
Ile 278 | Thr 278 | engineered mutation |
Pro 387 | Ala 387 | conflict |
Arg 388 | Lys 388 | conflict |
Ile 390 | Val 390 | conflict |
Phe 394 | Leu 394 | engineered mutation |
Asp 396 | Glu 396 | conflict |
Gly 398 | Gln 398 | conflict |
Ile 401 | Met 401 | engineered mutation |
Asn 402 | Arg 402 | engineered mutation |
Lys 404 | His 404 | engineered mutation |
Ile 409 | Met 409 | engineered mutation |
Tyr 410 | Val 410 | engineered mutation |
Arg 411 | His 411 | engineered mutation |
Lys 414 | Asn 414 | conflict |
Lys 415 | Arg 415 | conflict |
Ile 416 | Tyr 416 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 70790.4 | |
All* | Total formula weight | 70790.4 |