8DN4
Cryo-EM structure of human Glycine Receptor alpha-1 beta heteromer, glycine-bound state3(desensitized state)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | D, A, B, C | Glycine receptor subunit alpha-1 | polymer | 367 | 42421.1 | 4 | UniProt (P23415) Pfam (PF02931) Pfam (PF02932) In PDB | Homo sapiens (human) | Glycine receptor 48 kDa subunit,Glycine receptor strychnine-binding subunit |
| 2 | E | Glycine receptor subunit beta,Green fluorescent protein,Glycine receptor beta | polymer | 681 | 76698.6 | 1 | UniProt (P48167) UniProt (P42212) UniProt (A0A2K6CAQ3) Pfam (PF02931) Pfam (PF02932) Pfam (PF01353) In PDB | Homo sapiens (human) | |
| 3 | D, A, B, C, E | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
| 4 | D | PENTANE | non-polymer | 72.1 | 1 | Chemie (LNK) | |||
| 5 | D, A, B, C, E | HEXANE | non-polymer | 86.2 | 9 | Chemie (HEX) | |||
| 6 | D, C | N-BUTANE | non-polymer | 58.1 | 3 | Chemie (NBU) | |||
| 7 | A | N-OCTANE | non-polymer | 114.2 | 1 | Chemie (OCT) | |||
| 8 | C | nonane | non-polymer | 128.3 | 1 | Chemie (DD9) |
Sequence modifications
D, A, B, C: 1 - 428 (UniProt: P23415)
E: 3 - 334 (UniProt: P48167)
E: 334 - 343 (UniProt: P42212)
E: 343 - 475 (UniProt: A0A2K6CAQ3)
| PDB | External Database | Details |
|---|---|---|
| - | Arg 344 | deletion |
| - | Phe 345 | deletion |
| - | Arg 346 | deletion |
| - | Arg 347 | deletion |
| - | Lys 348 | deletion |
| - | Arg 349 | deletion |
| - | Arg 350 | deletion |
| - | His 351 | deletion |
| - | His 352 | deletion |
| - | Lys 353 | deletion |
| - | Ser 354 | deletion |
| - | Pro 355 | deletion |
| - | Met 356 | deletion |
| - | Leu 357 | deletion |
| - | Asn 358 | deletion |
| - | Leu 359 | deletion |
| - | Phe 360 | deletion |
| - | Gln 361 | deletion |
| - | Glu 362 | deletion |
| - | Asp 363 | deletion |
| - | Glu 364 | deletion |
| - | Ala 365 | deletion |
| - | Gly 366 | deletion |
| - | Glu 367 | deletion |
| - | Gly 368 | deletion |
| - | Arg 369 | deletion |
| - | Phe 370 | deletion |
| - | Asn 371 | deletion |
| - | Phe 372 | deletion |
| - | Ser 373 | deletion |
| - | Ala 374 | deletion |
| - | Tyr 375 | deletion |
| - | Gly 376 | deletion |
| - | Met 377 | deletion |
| - | Gly 378 | deletion |
| - | Pro 379 | deletion |
| - | Ala 380 | deletion |
| - | Cys 381 | deletion |
| - | Leu 382 | deletion |
| - | Gln 383 | deletion |
| - | Ala 384 | deletion |
| - | Lys 385 | deletion |
| - | Asp 386 | deletion |
| - | Gly 387 | deletion |
| - | Ile 388 | deletion |
| - | Ser 389 | deletion |
| - | Val 390 | deletion |
| - | Lys 391 | deletion |
| - | Gly 392 | deletion |
| - | Ala 393 | deletion |
| - | Asn 394 | deletion |
| - | Asn 395 | deletion |
| - | Ser 396 | deletion |
| - | Asn 397 | deletion |
| - | Thr 398 | deletion |
| - | Thr 399 | deletion |
| - | Asn 400 | deletion |
| - | Pro 401 | deletion |
| - | Pro 402 | deletion |
| - | Pro 403 | deletion |
| - | Ala 404 | deletion |
| - | Pro 405 | deletion |
| Gly 377 | Ser 406 | conflict |
| Ser 378 | Lys 407 | conflict |
| Gly 380 | Pro 409 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 334 | - | linker |
| Gly 334 | - | linker |
| Ser 334 | - | linker |
| Ser 334 | - | linker |
| Ala 334 | - | linker |
| Ala 334 | - | linker |
| Ala 334 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Val 334 | Met 1 | conflict |
| Ser 343 | - | linker |
| Gly 343 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Gly 343 | Thr 380 | conflict |
| Ser 343 | Leu 381 | conflict |
| Gly 343 | Gln 382 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 246383.1 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 2370.6 | |
| All* | Total formula weight | 248753.7 |
