8DKM
Cryo-EM structure of cystine-bound cystinosin in a lumen-open state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Fab 3H5 Heavy Chain | polymer | 250 | 26768.1 | 1 | Mus musculus | ||
| 2 | B | Fab 3H5 Kappa chain | polymer | 233 | 25468.4 | 1 | Mus musculus | ||
| 3 | P | Isoform 2 of Cystinosin | polymer | 408 | 46080.4 | 1 | UniProt (O60931) Pfam (PF04193) In PDB | Homo sapiens (human) | |
| 4 | P | L-cystine | non-polymer | 240.3 | 1 | Chemie (IYY) |
Sequence modifications
P: 1 - 400 (UniProt: O60931)
| PDB | External Database | Details |
|---|---|---|
| Ile 260 | Thr 260 | engineered mutation |
| Asp 401 | - | expression tag |
| Tyr 402 | - | expression tag |
| Lys 403 | - | expression tag |
| Asp 404 | - | expression tag |
| Asp 405 | - | expression tag |
| Asp 406 | - | expression tag |
| Asp 407 | - | expression tag |
| Lys 408 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 98316.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 240.3 | |
| All* | Total formula weight | 98557.2 |
