8DJ1

Crystal structure of NavAb V126T as a basis for the human Nav1.7 Inherited Erythromelalgia S241T mutation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Ion transport protein	polymer	257	29791.3	1	UniProt (A8EVM5) Pfam (PF00520) Pfam (PF08016) In PDB	Aliarcobacter butzleri RM4018
2	A	1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE	non-polymer		678.9	5	Chemie (PX4)
3	A	3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE	non-polymer		614.9	2	Chemie (CPS)
4		water	water		18.0	4	Chemie (HOH)

Sequence modifications

A: 1001 - 1239 (UniProt: A8EVM5)

PDB	External Database	Details
Met 983	-	initiating methionine
Asp 984	-	expression tag
Tyr 985	-	expression tag
Lys 986	-	expression tag
Asp 987	-	expression tag
Asp 988	-	expression tag
Asp 989	-	expression tag
Asp 990	-	expression tag
Lys 991	-	expression tag
Gly 992	-	expression tag
Ser 993	-	expression tag
Leu 994	-	expression tag
Val 995	-	expression tag
Pro 996	-	expression tag
Arg 997	-	expression tag
Gly 998	-	expression tag
Ser 999	-	expression tag
His 1000	-	expression tag
Thr 1126	Val 126	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	29791.3
Non-Polymers*	Number of molecules	7
	Total formula weight	4624.5
All*	Total formula weight	34415.7

*Water molecules are not included.