8DIR
The complex structure between human IgG1 Fc and its high affinity receptor FcgRI H174R variant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (B, A) | Ig gamma-1 Fc chain | polymer | 219 | 24699.0 | 2 | UniProt (P01857) Pfam (PF07654) | Homo sapiens (human) | IgG1 Fc |
| 2 | C (C) | High affinity immunoglobulin gamma Fc receptor I | polymer | 277 | 31201.3 | 1 | UniProt (P12314) Pfam (PF13927) Pfam (PF13895) Pfam (PF00047) | Homo sapiens (human) | IgG Fc receptor I,Fc-gamma RI,FcRI,Fc-gamma RIA,FcgammaRIa |
| 3 | D, E (D, E) | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1625.5 | 2 | In PDB GlyTouCan (G27919IH) | |||
| 4 | F, G, H (A, C) | SODIUM ION | non-polymer | 23.0 | 3 | Chemie (NA) | |||
| 5 | I, J, K (B, A, C) | water | water | 18.0 | 244 | Chemie (HOH) |
Sequence modifications
C: 21 - 289 (UniProt: P12314)
| PDB | External Database | Details |
|---|---|---|
| Ala 19 | - | expression tag |
| Pro 20 | - | expression tag |
| Lys 25 | Thr 25 | conflict |
| Ser 38 | Thr 38 | conflict |
| Pro 46 | Leu 46 | conflict |
| Ile 63 | Thr 63 | conflict |
| Thr 69 | Ser 69 | conflict |
| His 71 | Arg 71 | conflict |
| Glu 77 | Val 77 | conflict |
| Asp 78 | Asn 78 | conflict |
| Val 100 | Ile 100 | conflict |
| Leu 114 | Phe 114 | conflict |
| Met 160 | Ile 160 | conflict |
| Ser 163 | Asn 163 | conflict |
| Arg 174 | His 174 | conflict |
| Thr 195 | Asn 195 | conflict |
| Thr 206 | Asn 206 | conflict |
| Pro 207 | Leu 207 | conflict |
| Asp 240 | Asn 240 | conflict |
| His 283 | Leu 283 | conflict |
| Gln 285 | Leu 285 | conflict |
| His 290 | - | expression tag |
| His 291 | - | expression tag |
| His 292 | - | expression tag |
| His 293 | - | expression tag |
| His 294 | - | expression tag |
| His 295 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 80599.2 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 3251.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 69.0 | |
| All* | Total formula weight | 83919.2 |
