8DFI
Crystal structure of moderately neutralizing / interfering human monoclonal antibody 42C11 Fab in complex with MSP1-19
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Merozoite surface protein 1 | polymer | 105 | 11759.9 | 1 | UniProt (Q8I0U8) Pfam (PF12946) | Plasmodium falciparum 3D7 | Merozoite surface antigens,PMMSA |
| 2 | B (H) | 42C11 Fab Heavy Chain | polymer | 239 | 25667.8 | 1 | Homo sapiens (Human) | ||
| 3 | C (L) | 42C11 Fab Light Chain | polymer | 219 | 23239.9 | 1 | Homo sapiens (Human) | ||
| 4 | D, E, F (A, H, L) | water | water | 18.0 | 269 | Chemie (HOH) |
Sequence modifications
A: 1 - 93 (UniProt: Q8I0U8)
| PDB | External Database | Details |
|---|---|---|
| Glu -2 | - | expression tag |
| Thr -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Ala 3 | Ser 1609 | engineered mutation |
| Ala 48 | Thr 1654 | engineered mutation |
| Gly 94 | - | expression tag |
| Thr 95 | - | expression tag |
| Lys 96 | - | expression tag |
| His 97 | - | expression tag |
| His 98 | - | expression tag |
| His 99 | - | expression tag |
| His 100 | - | expression tag |
| His 101 | - | expression tag |
| His 102 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 60667.7 | |
| All* | Total formula weight | 60667.7 |
