8DFI

Crystal structure of moderately neutralizing / interfering human monoclonal antibody 42C11 Fab in complex with MSP1-19

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Merozoite surface protein 1	polymer	105	11759.9	1	UniProt (Q8I0U8) Pfam (PF12946) In PDB	Plasmodium falciparum 3D7	Merozoite surface antigens,PMMSA
2	H	42C11 Fab Heavy Chain	polymer	239	25667.8	1		Homo sapiens (Human)
3	L	42C11 Fab Light Chain	polymer	219	23239.9	1		Homo sapiens (Human)
4		water	water		18.0	269	Chemie (HOH)

Sequence modifications

A: 1 - 93 (UniProt: Q8I0U8)

PDB	External Database	Details
Glu -2	-	expression tag
Thr -1	-	expression tag
Gly 0	-	expression tag
Ala 3	Ser 1609	engineered mutation
Ala 48	Thr 1654	engineered mutation
Gly 94	-	expression tag
Thr 95	-	expression tag
Lys 96	-	expression tag
His 97	-	expression tag
His 98	-	expression tag
His 99	-	expression tag
His 100	-	expression tag
His 101	-	expression tag
His 102	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	60667.7
All*	Total formula weight	60667.7

*Water molecules are not included.