8DE1
TEM-1 beta-lactamase A237Y mutant covalently bound to avibactam
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Beta-lactamase TEM | polymer | 264 | 29061.1 | 4 | UniProt (P62593) Pfam (PF00144) Pfam (PF13354) | Escherichia coli | TEM-1 |
| 2 | E, F, G, H (A, B, C, D) | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide | non-polymer | 267.3 | 4 | Chemie (NXL) | |||
| 3 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 1270 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 26 - 288 (UniProt: P62593)
| PDB | External Database | Details |
|---|---|---|
| Gly 25 | - | expression tag |
| Thr 182 | Met 180 | engineered mutation |
| Tyr 237 | Ala 235 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 116244.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1069.0 | |
| All* | Total formula weight | 117313.3 |
