8DDB

The N-terminal domain of PA endonuclease from the influenza H1N1 viral polymerase in complex with 4-(benzyloxy)-6-bromo-3-hydroxypicolinic acid

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Polymerase acidic protein	polymer	191	22367.4	1	UniProt (C3W5S0) In PDB	Influenza A virus (A/California/04/2009(H1N1))	RNA-directed RNA polymerase subunit P2
2	A	MANGANESE (II) ION	non-polymer		54.9	2	Chemie (MN)
3	A	ACETATE ION	non-polymer		59.0	1	Chemie (ACT)
4	A	6-bromo-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid	non-polymer		234.0	1	Chemie (R6X)
5	A	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
6		water	water		18.0	80	Chemie (HOH)

Sequence modifications

A: 1 - 183 (UniProt: C3W5S0)

PDB	External Database	Details
Met -5	-	initiating methionine
Gly -4	-	expression tag
Ser -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
Ala 0	-	expression tag
-	His 52	deletion
-	Phe 53	deletion
-	Ile 54	deletion
-	Asp 55	deletion
-	Glu 56	deletion
-	Arg 57	deletion
-	Glu 59	deletion
-	Ser 60	deletion
-	Ile 61	deletion
-	Ile 62	deletion
-	Val 63	deletion
-	Glu 64	deletion
Glu 73	Lys 73	conflict
Ser 184	-	expression tag
Arg 185	-	expression tag
Ser 186	-	expression tag
Leu 187	-	expression tag
Trp 188	-	expression tag
Asp 189	-	expression tag
Ser 190	-	expression tag
Phe 191	-	expression tag
Arg 192	-	expression tag
Gln 193	-	expression tag
Ser 194	-	expression tag
Glu 195	-	expression tag
Arg 196	-	expression tag
Glu 197	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	22367.4
Non-Polymers*	Number of molecules	5
	Total formula weight	499.0
All*	Total formula weight	22866.4

*Water molecules are not included.