8DD6
SARS-CoV-2 Main Protease (Mpro) H163A Mutant in Complex with GC376
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | ORF1a polyprotein | polymer | 306 | 33758.5 | 1 | UniProt (A0A7U3EDN3) Pfam (PF05409) UniProt (by SIFTS) (P0DTD1) | Severe acute respiratory syndrome coronavirus 2 | |
| 2 | B (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 3 | C (A) | (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid | non-polymer | 485.6 | 1 | BIRD (PRD_002495) Chemie (K36) | |||
| 4 | D (A) | water | water | 18.0 | 79 | Chemie (HOH) |
Sequence modifications
A: 1 - 306 (UniProt: A0A7U3EDN3)
| PDB | External Database | Details |
|---|---|---|
| Ala 163 | His 3404 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33758.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 563.7 | |
| All* | Total formula weight | 34322.2 |
