8D6E

Crystal Structure of Human Myt1 Kinase domain Bounded with RP-6306

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (B, A)	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	polymer	311	34498.1	2	UniProt (Q99640) Pfam (PF00069)	Homo sapiens (human)	Myt1 kinase
2	C, N (B, A)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
3	D, O (B, A)	(1P)-2-amino-1-(3-hydroxy-2,6-dimethylphenyl)-5,6-dimethyl-1H-pyrrolo[2,3-b]pyridine-3-carboxamide	non-polymer		324.4	2	Chemie (QGI)
4	E, J, K (B)	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
5	F, G, H, I, L... (B, A)	1,2-ETHANEDIOL	non-polymer		62.1	12	Chemie (EDO)
6	V, W (B, A)	water	water		18.0	94	Chemie (HOH)

Sequence modifications

B, A: 75 - 362 (UniProt: Q99640)

PDB	External Database	Details
Met 52	-	initiating methionine
His 53	-	expression tag
His 54	-	expression tag
His 55	-	expression tag
His 56	-	expression tag
His 57	-	expression tag
His 58	-	expression tag
Ser 59	-	expression tag
Ser 60	-	expression tag
Gly 61	-	expression tag
Val 62	-	expression tag
Asp 63	-	expression tag
Leu 64	-	expression tag
Gly 65	-	expression tag
Thr 66	-	expression tag
Glu 67	-	expression tag
Asn 68	-	expression tag
Leu 69	-	expression tag
Tyr 70	-	expression tag
Phe 71	-	expression tag
Gln 72	-	expression tag
Ser 73	-	expression tag
Met 74	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	68996.3
Non-Polymers*	Number of molecules	19
	Total formula weight	1862.0
All*	Total formula weight	70858.2

*Water molecules are not included.