8D0H

Human SARM1 TIR domain bound to NB-3-GDPR

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	NAD(+) hydrolase SARM1	polymer	143	16205.6	2	UniProt (Q6SZW1) Pfam (PF13676) In PDB	Homo sapiens (human)	NADase SARM1,hSARM1,NADP(+) hydrolase SARM1,Sterile alpha and Armadillo repeat protein,Sterile alpha and TIR motif-containing protein 1,Sterile alpha motif domain-containing protein 2,MyD88-5,SAM domain-containing protein 2,Tir-1 homolog,HsTIR
2	A, B	[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-3~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-[4-[(1~{S})-1-[methyl-[2,2,2-tris(fluoranyl)ethylcarbamoyl]amino]ethyl]pyridin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate	non-polymer		819.6	2	Chemie (Q1O)
3		water	water		18.0	75	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	32411.1
Non-Polymers*	Number of molecules	2
	Total formula weight	1639.1
All*	Total formula weight	34050.3

*Water molecules are not included.