8D0B

Human CST-DNA polymerase alpha/primase preinitiation complex bound to 4xTEL-foldback template

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	CST complex subunit CTC1	polymer	1209	133938.1	1	UniProt (Q2NKJ3) Pfam (PF15489)	Homo sapiens (human)	Conserved telomere maintenance component 1,HBV DNAPTP1-transactivated protein B
2	B (B)	CST complex subunit STN1	polymer	362	41585.3	1	UniProt (Q9H668) Pfam (PF01336) Pfam (PF09170)	Homo sapiens (human)	Oligonucleotide/oligosaccharide-binding fold-containing protein 1,Suppressor of cdc thirteen homolog
3	C (C)	CST complex subunit TEN1	polymer	121	13609.6	1	UniProt (Q86WV5) Pfam (PF15490)	Homo sapiens (human)	Protein telomeric pathways with STN1 homolog,Telomere length regulation protein TEN1 homolog
4	D (D)	DNA primase small subunit	polymer	419	49849.8	1	UniProt (P49642) Pfam (PF01896)	Homo sapiens (human)	DNA primase 49 kDa subunit,p49
5	E (E)	DNA primase large subunit	polymer	241	28272.3	1	UniProt (P49643)	Homo sapiens (human)	DNA primase 58 kDa subunit,p58
6	F (F)	DNA polymerase alpha catalytic subunit	polymer	1139	130472.2	1	UniProt (P09884) Pfam (PF03104) Pfam (PF00136) Pfam (PF08996)	Homo sapiens (human)	DNA polymerase alpha catalytic subunit p180
7	G (G)	DNA polymerase alpha subunit B	polymer	456	50344.0	1	UniProt (Q14181) Pfam (PF04042) Pfam (PF22062)	Homo sapiens (human)	DNA polymerase alpha 70 kDa subunit
8	H (H)	DNA (5'-D(P*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*G)-3')	polymer	15	4720.1	1		Homo sapiens

Sequence modifications

A: 9 - 1217 (UniProt: Q2NKJ3)

PDB	External Database	Details
Val 820	Ile 820	conflict
Val 1005	Ile 1005	conflict

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	452791.3
All*	Total formula weight	452791.3

*Water molecules are not included.