8CX1
Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC dimeric complex in State 1
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, F | DNA dC->dU-editing enzyme APOBEC-3G | polymer | 421 | 50034.6 | 2 | UniProt (Q9HC16) Pfam (PF18782) Pfam (PF05240) In PDB | Homo sapiens (human) | APOBEC-related cytidine deaminase,APOBEC-related protein,ARCD,APOBEC-related protein 9,ARP-9,CEM-15,CEM15,Deoxycytidine deaminase,A3G |
2 | B, G | Virion infectivity factor | polymer | 192 | 22556.0 | 2 | UniProt (Q77YG0) Pfam (PF00559) UniProt (by SIFTS) (P69723) In PDB | Human immunodeficiency virus 1 | Vif,SOR protein |
3 | C, H | Core-binding factor subunit beta | polymer | 182 | 21542.2 | 2 | UniProt (Q13951) Pfam (PF02312) In PDB | Homo sapiens (human) | CBF-beta,Polyomavirus enhancer-binding protein 2 beta subunit,PEA2-beta,PEBP2-beta,SL3-3 enhancer factor 1 subunit beta,SL3/AKV core-binding factor beta subunit |
4 | D, I | Elongin-B | polymer | 118 | 13147.8 | 2 | UniProt (Q15370) Pfam (PF00240) In PDB | Homo sapiens (human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
5 | E, J | Elongin-C | polymer | 112 | 12485.1 | 2 | UniProt (Q15369) Pfam (PF03931) In PDB | Homo sapiens (human) | EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1 |
6 | K | RNA (5'-R(P*UP*AP*AP*AP*UP*AP*UP*U)-3') | polymer | 8 | 2496.5 | 1 | Spodoptera frugiperda (fall armyworm) | ||
7 | L | RNA (5'-R(P*AP*AP*AP*AP*UP*AP*UP*U)-3') | polymer | 8 | 2519.6 | 1 | Spodoptera frugiperda (fall armyworm) | ||
8 | A, B, F, G | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) |
Sequence modifications
A, F: 1 - 384 (UniProt: Q9HC16)
PDB | External Database | Details |
---|---|---|
Gly 385 | - | expression tag |
Ser 386 | - | expression tag |
Ser 387 | - | expression tag |
Leu 388 | - | expression tag |
Glu 389 | - | expression tag |
Gly 390 | - | expression tag |
Gly 391 | - | expression tag |
Gly 392 | - | expression tag |
Gly 393 | - | expression tag |
Trp 394 | - | expression tag |
Ser 395 | - | expression tag |
His 396 | - | expression tag |
Pro 397 | - | expression tag |
Gln 398 | - | expression tag |
Phe 399 | - | expression tag |
Glu 400 | - | expression tag |
Lys 401 | - | expression tag |
Gly 402 | - | expression tag |
Gly 403 | - | expression tag |
Gly 404 | - | expression tag |
Ser 405 | - | expression tag |
Gly 406 | - | expression tag |
Gly 407 | - | expression tag |
Gly 408 | - | expression tag |
Ser 409 | - | expression tag |
Gly 410 | - | expression tag |
Gly 411 | - | expression tag |
Gly 412 | - | expression tag |
Ser 413 | - | expression tag |
Trp 414 | - | expression tag |
Ser 415 | - | expression tag |
His 416 | - | expression tag |
Pro 417 | - | expression tag |
Gln 418 | - | expression tag |
Phe 419 | - | expression tag |
Glu 420 | - | expression tag |
Lys 421 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 12 |
Total formula weight | 244547.5 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 392.5 | |
All* | Total formula weight | 244940.0 |