8CX0
Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC monomeric complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | DNA dC->dU-editing enzyme APOBEC-3G | polymer | 421 | 50034.6 | 1 | UniProt (Q9HC16) Pfam (PF18782) Pfam (PF05240) In PDB | Homo sapiens (human) | APOBEC-related cytidine deaminase,APOBEC-related protein,ARCD,APOBEC-related protein 9,ARP-9,CEM-15,CEM15,Deoxycytidine deaminase,A3G |
| 2 | B | Virion infectivity factor | polymer | 192 | 22556.0 | 1 | UniProt (Q77YG0) Pfam (PF00559) UniProt (by SIFTS) (P69723) In PDB | Human immunodeficiency virus 1 | Vif,SOR protein |
| 3 | C | Core-binding factor subunit beta | polymer | 182 | 21542.2 | 1 | UniProt (Q13951) Pfam (PF02312) In PDB | Homo sapiens (human) | CBF-beta,Polyomavirus enhancer-binding protein 2 beta subunit,PEA2-beta,PEBP2-beta,SL3-3 enhancer factor 1 subunit beta,SL3/AKV core-binding factor beta subunit |
| 4 | D | Elongin-B | polymer | 118 | 13147.8 | 1 | UniProt (Q15370) Pfam (PF00240) In PDB | Homo sapiens (human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 5 | E | Elongin-C | polymer | 112 | 12485.1 | 1 | UniProt (Q15369) Pfam (PF03931) In PDB | Homo sapiens (human) | EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1 |
| 6 | K | RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*A)-3') | polymer | 8 | 2588.7 | 1 | Spodoptera frugiperda (fall armyworm) | ||
| 7 | A, B | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) |
Sequence modifications
A: 1 - 384 (UniProt: Q9HC16)
| PDB | External Database | Details |
|---|---|---|
| Gly 385 | - | expression tag |
| Ser 386 | - | expression tag |
| Ser 387 | - | expression tag |
| Leu 388 | - | expression tag |
| Glu 389 | - | expression tag |
| Gly 390 | - | expression tag |
| Gly 391 | - | expression tag |
| Gly 392 | - | expression tag |
| Gly 393 | - | expression tag |
| Trp 394 | - | expression tag |
| Ser 395 | - | expression tag |
| His 396 | - | expression tag |
| Pro 397 | - | expression tag |
| Gln 398 | - | expression tag |
| Phe 399 | - | expression tag |
| Glu 400 | - | expression tag |
| Lys 401 | - | expression tag |
| Gly 402 | - | expression tag |
| Gly 403 | - | expression tag |
| Gly 404 | - | expression tag |
| Ser 405 | - | expression tag |
| Gly 406 | - | expression tag |
| Gly 407 | - | expression tag |
| Gly 408 | - | expression tag |
| Ser 409 | - | expression tag |
| Gly 410 | - | expression tag |
| Gly 411 | - | expression tag |
| Gly 412 | - | expression tag |
| Ser 413 | - | expression tag |
| Trp 414 | - | expression tag |
| Ser 415 | - | expression tag |
| His 416 | - | expression tag |
| Pro 417 | - | expression tag |
| Gln 418 | - | expression tag |
| Phe 419 | - | expression tag |
| Glu 420 | - | expression tag |
| Lys 421 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 122354.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 196.2 | |
| All* | Total formula weight | 122550.6 |
