8CWU

Crystal structure of SARS-CoV-2 spike protein receptor-binding domain in complex with a cross-neutralizing nanobody 1-21

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Spike protein S1	polymer	205	23104.9	1	UniProt (P0DTC2) Pfam (PF09408) In PDB	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 2019-nCoV)
2	B	VHH 1-21	polymer	151	16370.2	1		Lama glama
3	C	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	1	In PDB GlyTouCan (G21290RB)
4		water	water		18.0	267	Chemie (HOH)

Sequence modifications

A: 333 - 530 (UniProt: P0DTC2)

PDB	External Database	Details
Gly 531	-	expression tag
His 532	-	expression tag
His 533	-	expression tag
His 534	-	expression tag
His 535	-	expression tag
His 536	-	expression tag
His 537	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	39475.1
Branched	Number of molecules	1
	Total formula weight	570.5
All*	Total formula weight	40045.7

*Water molecules are not included.