8CTC
Human excitatory amino acid transporter 3 (EAAT3) with bound glutamate in an intermediate outward facing state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Excitatory amino acid transporter 3 | polymer | 526 | 57120.9 | 3 | UniProt (P43005) Pfam (PF00375) | Homo sapiens (human) | Excitatory amino-acid carrier 1,Neuronal and epithelial glutamate transporter,Sodium-dependent glutamate/aspartate transporter 3,Solute carrier family 1 member 1 |
| 2 | D, I, N (A, B, C) | GLUTAMIC ACID | non-polymer | 147.1 | 3 | Chemie (GLU) | |||
| 3 | E, F, G, J, K... (A, B, C) | SODIUM ION | non-polymer | 23.0 | 9 | Chemie (NA) | |||
| 4 | H, M, R (A, B, C) | MERCURY (II) ION | non-polymer | 200.6 | 3 | Chemie (HG) | |||
| 5 | S, T, U (A, B, C) | water | water | 18.0 | 12 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 524 (UniProt: P43005)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Pro 0 | - | expression tag |
| Ala 9 | Cys 9 | engineered mutation |
| Ala 100 | Cys 100 | engineered mutation |
| Ala 158 | Cys 158 | engineered mutation |
| Thr 178 | Asn 178 | engineered mutation |
| Thr 195 | Asn 195 | engineered mutation |
| Ala 219 | Cys 219 | engineered mutation |
| Trp 256 | Cys 256 | engineered mutation |
| Cys 269 | Lys 269 | engineered mutation |
| Cys 441 | Trp 441 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 171362.6 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 1250.1 | |
| All* | Total formula weight | 172612.7 |
