8CRH
Crystal structure of Candida auris dihydrofolate reductase complexed with NADPH and cycloguanil
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (B, A) | Dihydrofolate reductase | polymer | 208 | 24047.6 | 2 | UniProt (A0A0L0P1H8) | [Candida] auris | |
| 2 | C, E, G, I (B, A) | 5-(4-chlorophenyl)-6,6-dimethyl-1,4-dihydro-1,3,5-triazine-2,4-diamine | non-polymer | 253.7 | 4 | Chemie (VIL) | |||
| 3 | D, H (B, A) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 2 | Chemie (NDP) | |||
| 4 | F, J, K, L, M (B, A) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 5 | N, O (B, A) | water | water | 18.0 | 623 | Chemie (HOH) |
Sequence modifications
B, A: 0 - 203 (UniProt: A0A0L0P1H8)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Ser -3 | - | expression tag |
| His -2 | - | expression tag |
| Met -1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 48095.2 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 2986.1 | |
| All* | Total formula weight | 51081.3 |
