8CQ8
Mycobacterium tuberculosis dihydrofolate reductase in complex with methyl 4-(2,6-diamino-5-(cyclopropylethynyl)pyrimidin-4-yl)benzoate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Dihydrofolate reductase | polymer | 161 | 17893.3 | 2 | UniProt (A0A0E8UVJ4) Pfam (PF00186) UniProt (by SIFTS) (P9WNX1) | Mycobacterium tuberculosis | |
| 2 | C, I (A, B) | methyl 4-[2,6-bis(azanyl)-5-(2-cyclopropylethynyl)pyrimidin-4-yl]benzoate | non-polymer | 308.3 | 2 | Chemie (VFF) | |||
| 3 | D, J, K (A, B) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 3 | Chemie (MES) | |||
| 4 | E, L (A, B) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 2 | Chemie (NDP) | |||
| 5 | F, M (A, B) | COBALT (II) ION | non-polymer | 58.9 | 2 | Chemie (CO) | |||
| 6 | G, H, N, O (A, B) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 7 | P, Q (A, B) | water | water | 18.0 | 125 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35786.6 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 3195.3 | |
| All* | Total formula weight | 38981.9 |
