8COJ

Crystal structure of human soluble adenylyl cyclase catalytic domain in complex with the inhibitor TDI-10228

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Adenylate cyclase type 10	polymer	475	54269.7	1	UniProt (Q96PN6) Pfam (PF00211) In PDB	Homo sapiens (human)	AH-related protein,Adenylate cyclase homolog,Germ cell soluble adenylyl cyclase,sAC,Testicular soluble adenylyl cyclase
2	A	4-chloranyl-6-[4-[(3-fluorophenyl)methyl]-1-methyl-pyrazol-3-yl]pyrimidin-2-amine	non-polymer		317.7	1	Chemie (VE1)
3	A	DIMETHYL SULFOXIDE	non-polymer		78.1	4	Chemie (DMS)
4	A	ACETATE ION	non-polymer		59.0	1	Chemie (ACT)
5	A	1,2-ETHANEDIOL	non-polymer		62.1	6	Chemie (EDO)
6		water	water		18.0	120	Chemie (HOH)

Sequence modifications

A: 1 - 469 (UniProt: Q96PN6)

PDB	External Database	Details
His 470	-	expression tag
His 471	-	expression tag
His 472	-	expression tag
His 473	-	expression tag
His 474	-	expression tag
His 475	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	54269.7
Non-Polymers*	Number of molecules	12
	Total formula weight	1061.7
All*	Total formula weight	55331.4

*Water molecules are not included.