8CO7
Crystal structure of human soluble adenylyl cyclase (sAC) in complex with inhibitor TDI-09066
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Adenylate cyclase type 10 | polymer | 475 | 54269.7 | 1 | UniProt (Q96PN6) Pfam (PF00211) In PDB | Homo sapiens (human) | AH-related protein,Adenylate cyclase homolog,Germ cell soluble adenylyl cyclase,sAC,Testicular soluble adenylyl cyclase |
2 | A | 4-chloranyl-6-[1-methyl-4-(thiophen-2-ylmethyl)pyrazol-3-yl]pyrimidin-2-amine | non-polymer | 305.8 | 1 | Chemie (V9E) | |||
3 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 4 | Chemie (DMS) | |||
4 | A | ACETATE ION | non-polymer | 59.0 | 5 | Chemie (ACT) | |||
5 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 6 | Chemie (EDO) | |||
6 | A | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
7 | A | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
8 | A | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
9 | water | water | 18.0 | 208 | Chemie (HOH) |
Sequence modifications
A: 1 - 469 (UniProt: Q96PN6)
PDB | External Database | Details |
---|---|---|
His 470 | - | expression tag |
His 471 | - | expression tag |
His 472 | - | expression tag |
His 473 | - | expression tag |
His 474 | - | expression tag |
His 475 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 54269.7 | |
Non-Polymers* | Number of molecules | 20 |
Total formula weight | 1701.3 | |
All* | Total formula weight | 55970.9 |