8CNH
Crystal structure of human soluble adenylyl cyclase (sAC) in complex with inhibitor TDI-10512
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Adenylate cyclase type 10 | polymer | 475 | 54269.7 | 1 | UniProt (Q96PN6) Pfam (PF00211) | Homo sapiens (human) | AH-related protein,Adenylate cyclase homolog,Germ cell soluble adenylyl cyclase,sAC,Testicular soluble adenylyl cyclase |
| 2 | B (A) | methyl 2-[[3-(2-azanyl-6-chloranyl-pyrimidin-4-yl)-1-methyl-pyrazol-4-yl]methyl]benzoate | non-polymer | 357.8 | 1 | Chemie (V6U) | |||
| 3 | C, D, E, G, M (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 5 | Chemie (DMS) | |||
| 4 | F, H, I, J, K... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 9 | Chemie (EDO) | |||
| 5 | N (A) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 6 | R (A) | water | water | 18.0 | 125 | Chemie (HOH) |
Sequence modifications
A: 1 - 469 (UniProt: Q96PN6)
| PDB | External Database | Details |
|---|---|---|
| His 470 | - | expression tag |
| His 471 | - | expression tag |
| His 472 | - | expression tag |
| His 473 | - | expression tag |
| His 474 | - | expression tag |
| His 475 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 54269.7 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 1366.1 | |
| All* | Total formula weight | 55635.8 |
