8CND
Crystal structure of CREBBP-Y1482N histone acetyltransferase domain in complex with a bisubstrate inhibitor, Lys-CoA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | histone acetyltransferase | polymer | 640 | 75019.3 | 1 | UniProt (F8VPR5) Pfam (PF00439) Pfam (PF06001) Pfam (PF08214) Pfam (PF00569) UniProt (by SIFTS) (P45481) | Mus musculus (house mouse) | |
| 2 | B, C, D, E, G (A) | ZINC ION | non-polymer | 65.4 | 5 | Chemie (ZN) | |||
| 3 | F (A) | [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R,20R)-20-carbamoyl-3-hydroxy-2,2-dimethyl-4,8,14,22-tetraoxo-12-thia-5,9,15,21-tetraazatricos-1-yl dihydrogen diphosphate | non-polymer | 994.8 | 1 | Chemie (01K) |
Sequence modifications
A: 1085 - 1555 (UniProt: F8VPR5)
A: 1618 - 1750 (UniProt: F8VPR5)
| PDB | External Database | Details |
|---|---|---|
| His 1054 | - | expression tag |
| His 1055 | - | expression tag |
| His 1056 | - | expression tag |
| His 1057 | - | expression tag |
| His 1058 | - | expression tag |
| His 1059 | - | expression tag |
| Asp 1060 | - | expression tag |
| Tyr 1061 | - | expression tag |
| Asp 1062 | - | expression tag |
| Ile 1063 | - | expression tag |
| Pro 1064 | - | expression tag |
| Thr 1065 | - | expression tag |
| Thr 1066 | - | expression tag |
| Glu 1067 | - | expression tag |
| Asn 1068 | - | expression tag |
| Leu 1069 | - | expression tag |
| Tyr 1070 | - | expression tag |
| Phe 1071 | - | expression tag |
| Gln 1072 | - | expression tag |
| Gly 1073 | - | expression tag |
| Ala 1074 | - | expression tag |
| Met 1075 | - | expression tag |
| Gly 1076 | - | expression tag |
| Ser 1077 | - | expression tag |
| Ser 1078 | - | expression tag |
| Gln 1079 | - | expression tag |
| Pro 1080 | - | expression tag |
| Arg 1081 | - | expression tag |
| Lys 1082 | - | expression tag |
| Lys 1083 | - | expression tag |
| Ile 1084 | - | expression tag |
| Asn 1482 | Tyr 1483 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 1613 | - | linker |
| Gly 1614 | - | linker |
| Gly 1615 | - | linker |
| Ser 1616 | - | linker |
| Gly 1617 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 75019.3 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1321.8 | |
| All* | Total formula weight | 76341.2 |
