8CLL

Structural insights into human TFIIIC promoter recognition

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, F)	General transcription factor 3C polypeptide 1	polymer	2158	244200.7	2	UniProt (Q12789) Pfam (PF04182)	Homo sapiens (human)	TF3C-alpha,TFIIIC box B-binding subunit,Transcription factor IIIC 220 kDa subunit,TFIIIC 220 kDa subunit,TFIIIC220,Transcription factor IIIC subunit alpha
2	B, E (B, G)	General transcription factor 3C polypeptide 4	polymer	822	92093.2	2	UniProt (Q9UKN8) Pfam (PF12657) Pfam (PF19336) Pfam (PF12660)	Homo sapiens (human)	TF3C-delta,Transcription factor IIIC 90 kDa subunit,TFIIIC 90 kDa subunit,TFIIIC90,Transcription factor IIIC subunit delta
3	C, F (C, H)	General transcription factor 3C polypeptide 2	polymer	925	102612.5	2	UniProt (Q8WUA4) Pfam (PF00400)	Homo sapiens (human)	TF3C-beta,Transcription factor IIIC 110 kDa subunit,TFIIIC 110 kDa subunit,TFIIIC110,Transcription factor IIIC subunit beta
4	G, H, I, J (B, G)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)

Sequence modifications

A, F: 1 - 2109 (UniProt: Q12789)

PDB	External Database	Details
Gly 2110	-	expression tag
Gly 2111	-	expression tag
Gly 2112	-	expression tag
Ser 2113	-	expression tag
Gly 2114	-	expression tag
Gly 2115	-	expression tag
Gly 2116	-	expression tag
Ser 2117	-	expression tag
Gly 2118	-	expression tag
Gly 2119	-	expression tag
Ser 2120	-	expression tag
Leu 2121	-	expression tag
Glu 2122	-	expression tag
Val 2123	-	expression tag
Leu 2124	-	expression tag
Phe 2125	-	expression tag
Gln 2126	-	expression tag
Gly 2127	-	expression tag
Pro 2128	-	expression tag
Gly 2129	-	expression tag
Ser 2130	-	expression tag
Gly 2131	-	expression tag
Ser 2132	-	expression tag
Asp 2133	-	expression tag
Tyr 2134	-	expression tag
Lys 2135	-	expression tag
Asp 2136	-	expression tag
Asp 2137	-	expression tag
Asp 2138	-	expression tag
Asp 2139	-	expression tag
Lys 2140	-	expression tag
Gly 2141	-	expression tag
Asp 2142	-	expression tag
Tyr 2143	-	expression tag
Lys 2144	-	expression tag
Asp 2145	-	expression tag
Asp 2146	-	expression tag
Asp 2147	-	expression tag
Asp 2148	-	expression tag
Lys 2149	-	expression tag
Gly 2150	-	expression tag
Asp 2151	-	expression tag
Tyr 2152	-	expression tag
Lys 2153	-	expression tag
Asp 2154	-	expression tag
Asp 2155	-	expression tag
Asp 2156	-	expression tag
Asp 2157	-	expression tag
Lys 2158	-	expression tag

C, H: 1 - 911 (UniProt: Q8WUA4)

PDB	External Database	Details
Met -13	-	initiating methionine
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Gly 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	877812.7
Non-Polymers*	Number of molecules	4
	Total formula weight	261.6
All*	Total formula weight	878074.4

*Water molecules are not included.