8CLH
Drug cocktail (Colchicine, Epothilone A, Peloruside, Ansamitocin P3, Vinblastine) bound to tubulin (T2R-TTL) complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Tubulin alpha-1B chain | polymer | 440 | 48966.3 | 2 | UniProt (P81947) Pfam (PF00091) Pfam (PF03953) | Bos taurus (cattle) | |
| 2 | B, D (B, D) | Tubulin beta-2B chain | polymer | 430 | 48260.2 | 2 | UniProt (Q6B856) Pfam (PF00091) Pfam (PF03953) | Bos taurus (cattle) | |
| 3 | E (E) | Stathmin-4 | polymer | 138 | 16282.5 | 1 | UniProt (P63043) Pfam (PF00836) | Rattus norvegicus (Norway rat) | Stathmin-like protein B3,RB3 |
| 4 | F (F) | Tubulin tyrosine ligase | polymer | 381 | 43964.1 | 1 | UniProt (E1BQ43) Pfam (PF03133) UniProt (by SIFTS) (A0A8V0Z8P0) | Gallus gallus (chicken) | |
| 5 | G, P (A, C) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 2 | Chemie (GTP) | |||
| 6 | H, K, Q, T (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 7 | I, R (A, C) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 8 | J, S (B, D) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) | |||
| 9 | L (B) | N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide | non-polymer | 399.4 | 1 | Chemie (LOC) | |||
| 10 | M, U (B, D) | EPOTHILONE A | non-polymer | 493.7 | 2 | Chemie (EP) | |||
| 11 | N (B) | Peloruside A | non-polymer | 548.7 | 1 | Chemie (POU) | |||
| 12 | O (C) | (2ALPHA,2'BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE | non-polymer | 811.0 | 1 | Chemie (VLB) | |||
| 13 | V (D) | (1S,2S,3S,5S,6S,16Z,18Z,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl 2-methylpropanoate | non-polymer | 635.1 | 1 | Chemie (BKF) | |||
| 14 | W (F) | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | non-polymer | 505.2 | 1 | Chemie (ACP) | |||
| 15 | AA, BA, CA, X, Y... (D, E, F, A, B...) | water | water | 18.0 | 126 | Chemie (HOH) |
Sequence modifications
F: 1 - 378 (UniProt: E1BQ43)
| PDB | External Database | Details |
|---|---|---|
| His 379 | - | expression tag |
| His 380 | - | expression tag |
| His 381 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 254699.7 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 5996.9 | |
| All* | Total formula weight | 260696.5 |
