8CLD

Ansamitocin P3 bound to tubulin (T2R-TTL) complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Detyrosinated tubulin alpha-1B chain	polymer	451	50204.4	2	UniProt (P81947) Pfam (PF00091) Pfam (PF03953)	Bos taurus (cattle)
2	B, D (B, D)	Tubulin beta-2B chain	polymer	445	49999.9	2	UniProt (Q6B856) Pfam (PF00091) Pfam (PF03953)	Bos taurus (cattle)
3	E (E)	Stathmin-4	polymer	189	22125.3	1	UniProt (P63042) Pfam (PF00836) UniProt (by SIFTS) (P63043)	Mus musculus
4	F (F)	Tubulin tyrosine ligase	polymer	384	44378.5	1	UniProt (A0A8C9FGJ1) Pfam (PF03133) UniProt (by SIFTS) (A0A8V0Z8P0)	Pavo cristatus
5	G, L (A, C)	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	2	Chemie (GTP)
6	H, K, M (A, B, C)	MAGNESIUM ION	non-polymer		24.3	3	Chemie (MG)
7	I, N (A, C)	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
8	J, O (B, D)	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	2	Chemie (GDP)
9	P (D)	(1S,2S,3S,5S,6S,16Z,18Z,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl 2-methylpropanoate	non-polymer		635.1	1	Chemie (BKF)
10	Q (F)	PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER	non-polymer		505.2	1	Chemie (ACP)
11	R, S, T (A, C, E)	water	water		18.0	3	Chemie (HOH)

Sequence modifications

F: 1 - 378 (UniProt: A0A8C9FGJ1)

PDB	External Database	Details
His 379	-	expression tag
His 380	-	expression tag
His 381	-	expression tag
His 382	-	expression tag
His 383	-	expression tag
His 384	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	266912.5
Non-Polymers*	Number of molecules	11
	Total formula weight	3226.2
All*	Total formula weight	270138.6

*Water molecules are not included.