8CJM
Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-07-047
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tryptophan 5-hydroxylase 1 | polymer | 326 | 37424.6 | 1 | UniProt (P17752) Pfam (PF00351) | Homo sapiens (human) | Tryptophan 5-monooxygenase 1 |
| 2 | B (A) | FE (III) ION | non-polymer | 55.8 | 1 | Chemie (FE) | |||
| 3 | C (A) | 7-(cyclobutylmethyl)-3-ethyl-8-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-ylmethyl)purine-2,6-dione | non-polymer | 382.5 | 1 | Chemie (UXL) | |||
| 4 | D (A) | water | water | 18.0 | 120 | Chemie (HOH) |
Sequence modifications
A: 105 - 401 (UniProt: P17752)
| PDB | External Database | Details |
|---|---|---|
| Met 76 | - | initiating methionine |
| Lys 77 | - | expression tag |
| His 78 | - | expression tag |
| His 79 | - | expression tag |
| His 80 | - | expression tag |
| His 81 | - | expression tag |
| His 82 | - | expression tag |
| His 83 | - | expression tag |
| His 84 | - | expression tag |
| Gly 85 | - | expression tag |
| Ala 86 | - | expression tag |
| Ala 87 | - | expression tag |
| Gly 88 | - | expression tag |
| Thr 89 | - | expression tag |
| Ser 90 | - | expression tag |
| Leu 91 | - | expression tag |
| Tyr 92 | - | expression tag |
| Lys 93 | - | expression tag |
| Lys 94 | - | expression tag |
| Ala 95 | - | expression tag |
| Gly 96 | - | expression tag |
| Glu 97 | - | expression tag |
| Asn 98 | - | expression tag |
| Leu 99 | - | expression tag |
| Tyr 100 | - | expression tag |
| Phe 101 | - | expression tag |
| Gln 102 | - | expression tag |
| Gly 103 | - | expression tag |
| Ser 104 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37424.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 438.3 | |
| All* | Total formula weight | 37862.9 |
