8CIJ
CRYSTAL STRUCTURE OF HUMAN HPK1 (MAP4K1) COMPLEX WITH 2-[8-Amino-7-fluoro-6-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-isoquinolin-3-ylamino]-6-isopropyl-5,6-dihydro-4H-1,6,8a-triaza-azulen-7-one
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mitogen-activated protein kinase kinase kinase kinase 1 | polymer | 307 | 34360.8 | 1 | UniProt (Q92918) Pfam (PF00069) | Homo sapiens (human) | Hematopoietic progenitor kinase,MAPK/ERK kinase kinase kinase 1,MEK kinase kinase 1,MEKKK 1 |
| 2 | B (A) | 2-[[8-azanyl-7-fluoranyl-6-(8-methyl-2,3-dihydro-1~{H}-pyrido[2,3-b][1,4]oxazin-7-yl)isoquinolin-3-yl]amino]-6-propan-2-yl-5,8-dihydro-4~{H}-pyrazolo[1,5-d][1,4]diazepin-7-one | non-polymer | 516.6 | 1 | Chemie (USF) | |||
| 3 | C (A) | water | water | 18.0 | 7 | Chemie (HOH) |
Sequence modifications
A: 1 - 307 (UniProt: Q92918)
| PDB | External Database | Details |
|---|---|---|
| Glu 165 | Thr 165 | conflict |
| Glu 171 | Ser 171 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34360.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 516.6 | |
| All* | Total formula weight | 34877.3 |
