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8CHI

Human FKBP12 in complex with (1S,5S,6R)-10-((S)-3,5-dichloro-N-methylphenylsulfonimidoyl)-3-(pyridin-2-ylmethyl)-5-vinyl-3,10-diazabicyclo[4.3.1]decan-2-one

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BPeptidyl-prolyl cis-trans isomerase FKBP1Apolymer10711832.52UniProt (P62942)
Pfam (PF00254)
In PDB
Homo sapiens (human)PPIase FKBP1A,12 kDa FK506-binding protein,12 kDa FKBP,FKBP-12,Calstabin-1,FK506-binding protein 1A,FKBP-1A,Immunophilin FKBP12,Rotamase
2A, B(1S,5S,6R)-10-[S-[3,5-bis(chloranyl)phenyl]-N-methyl-sulfonimidoyl]-5-ethenyl-3-(pyridin-2-ylmethyl)-3,10-diazabicyclo[4.3.1]decan-2-onenon-polymer493.42Chemie (UMR)
3BDIMETHYL SULFOXIDEnon-polymer78.11Chemie (DMS)
4waterwater18.0253Chemie (HOH)
Sequence modifications
A, B: 1 - 107 (UniProt: P62942)
PDBExternal DatabaseDetails
Val 22Cys 23engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight23665.0
Non-Polymers*Number of molecules3
Total formula weight1065.0
All*Total formula weight24730.0
*Water molecules are not included.

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PDB entries from 2024-06-12

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