8CGC
Structure of CSF1R in complex with a pyrollopyrimidine (compound 23)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Macrophage colony-stimulating factor 1 receptor | polymer | 343 | 38660.3 | 1 | UniProt (P07333) Pfam (PF07714) | Homo sapiens (human) | CSF-1 receptor,CSF-1-R,CSF-1R,M-CSF-R,Proto-oncogene c-Fms |
| 2 | B (A) | (2S)-2-hydroxybutanedioic acid | non-polymer | 134.1 | 1 | Chemie (LMR) | |||
| 3 | C (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | D (A) | [4-[4-[methyl-[(3-methylphenyl)methyl]amino]-7~{H}-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]methanol | non-polymer | 358.4 | 1 | Chemie (UIK) | |||
| 5 | E (A) | water | water | 18.0 | 379 | Chemie (HOH) |
Sequence modifications
A: 542 - 919 (UniProt: P07333)
| PDB | External Database | Details |
|---|---|---|
| Met 531 | - | initiating methionine |
| Lys 532 | - | expression tag |
| Lys 533 | - | expression tag |
| Gly 534 | - | expression tag |
| His 535 | - | expression tag |
| His 536 | - | expression tag |
| His 537 | - | expression tag |
| His 538 | - | expression tag |
| His 539 | - | expression tag |
| His 540 | - | expression tag |
| Gly 541 | - | expression tag |
| - | Gly 696 | deletion |
| - | Val 697 | deletion |
| - | Asp 698 | deletion |
| - | Tyr 699 | deletion |
| - | Lys 700 | deletion |
| - | Asn 701 | deletion |
| - | Ile 702 | deletion |
| - | His 703 | deletion |
| - | Leu 704 | deletion |
| - | Glu 705 | deletion |
| - | Lys 706 | deletion |
| - | Lys 707 | deletion |
| - | Tyr 708 | deletion |
| - | Val 709 | deletion |
| - | Arg 710 | deletion |
| - | Arg 711 | deletion |
| - | Asp 712 | deletion |
| - | Ser 713 | deletion |
| - | Gly 714 | deletion |
| - | Phe 715 | deletion |
| - | Ser 716 | deletion |
| - | Ser 717 | deletion |
| - | Gln 718 | deletion |
| - | Gly 719 | deletion |
| - | Val 720 | deletion |
| - | Asp 721 | deletion |
| - | Thr 722 | deletion |
| - | Tyr 723 | deletion |
| - | Val 724 | deletion |
| - | Glu 725 | deletion |
| - | Met 726 | deletion |
| - | Arg 727 | deletion |
| - | Pro 728 | deletion |
| - | Val 729 | deletion |
| - | Ser 730 | deletion |
| - | Thr 731 | deletion |
| - | Ser 732 | deletion |
| - | Ser 733 | deletion |
| - | Asn 734 | deletion |
| - | Asp 735 | deletion |
| - | Ser 736 | deletion |
| - | Phe 737 | deletion |
| - | Ser 738 | deletion |
| - | Glu 739 | deletion |
| - | Gln 740 | deletion |
| - | Asp 741 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 38660.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 584.6 | |
| All* | Total formula weight | 39244.9 |
