8CDN

Crystal structure of human Brachyury in complex with a single T box binding element DNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	T-box transcription factor T	polymer	192	22022.4	1	UniProt (O15178) Pfam (PF00907)	Homo sapiens (human)	Brachyury protein,Protein T
2	B (C)	DNA (5'-D(*AP*GP*GP*TP*GP*TP*GP*AP*GP*CP*CP*T)-3')	polymer	12	3718.4	1		Homo sapiens
3	C (D)	DNA (5'-D(*AP*GP*GP*CP*TP*CP*AP*CP*AP*CP*CP*T)-3')	polymer	12	3607.4	1		Homo sapiens
4	D (A)	water	water		18.0	2	Chemie (HOH)

Sequence modifications

A: 41 - 224 (UniProt: O15178)

PDB	External Database	Details
Met 39	-	initiating methionine
Gly 40	-	expression tag
His 225	-	expression tag
His 226	-	expression tag
His 227	-	expression tag
His 228	-	expression tag
His 229	-	expression tag
His 230	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	29348.2
All*	Total formula weight	29348.2

*Water molecules are not included.