8CBL
Structure of human mitochondrial RNase Z in complex with mitochondrial pre-tRNA-His(0,Ser)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | 3-hydroxyacyl-CoA dehydrogenase type-2 | polymer | 261 | 26947.0 | 4 | UniProt (Q99714) Pfam (PF00106) | Homo sapiens (human) | 17-beta-estradiol 17-dehydrogenase,2-methyl-3-hydroxybutyryl-CoA dehydrogenase,MHBD,3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+)),3-hydroxy-2-methylbutyryl-CoA dehydrogenase,3-hydroxyacyl-CoA dehydrogenase type II,3alpha(or 20beta)-hydroxysteroid dehydrogenase,7-alpha-hydroxysteroid dehydrogenase,Endoplasmic reticulum-associated amyloid beta-peptide-binding protein,Mitochondrial ribonuclease P protein 2,Mitochondrial RNase P protein 2,Short chain dehydrogenase/reductase family 5C member 1,Short-chain type dehydrogenase/reductase XH98G2,Type II HADH |
| 2 | E (E) | Zinc phosphodiesterase ELAC protein 2 | polymer | 826 | 92281.0 | 1 | UniProt (Q9BQ52) Pfam (PF13691) Pfam (PF23023) | Homo sapiens (human) | ElaC homolog protein 2,Heredity prostate cancer protein 2,Ribonuclease Z 2,RNase Z 2,tRNA 3 endonuclease 2,tRNase Z 2 |
| 3 | F (F) | tRNA methyltransferase 10 homolog C | polymer | 408 | 48007.8 | 1 | UniProt (Q7L0Y3) | Homo sapiens (human) | HBV pre-S2 trans-regulated protein 2,Mitochondrial ribonuclease P protein 1,Mitochondrial RNase P protein 1,RNA (guanine-9-)-methyltransferase domain-containing protein 1,Renal carcinoma antigen NY-REN-49,mRNA methyladenosine-N(1)-methyltransferase,tRNA (adenine(9)-N(1))-methyltransferase,tRNA (guanine(9)-N(1))-methyltransferase |
| 4 | G (T) | Mitochondrial Precursor tRNA-His(0,Ser) | polymer | 128 | 40867.3 | 1 | Homo sapiens (Human) | ||
| 5 | H, I, J, K (A, B, C, D) | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 4 | Chemie (NAD) | |||
| 6 | L (E) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 7 | M (F) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) PubChem (16760024) PubChem (193) PubChem (25210495) PubChem (13792) PubChem (177678424) PubChem (44361184) PubChem (21125603) PubChem (46936206) PubChem (50989525) PubChem (25203782) PubChem (51380914) PubChem (52224398) PubChem (189149) PubChem (57544532) PubChem (439155) PubChem (59046843) PubChem (59170628) PubChem (59576228) PubChem (66805708) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (52224400) PubChem (5284331) PubChem (6419189) PubChem (118374891) PubChem (118560068) PubChem (71170554) PubChem (13231890) PubChem (164157219) PubChem (126969526) PubChem (129105892) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525) |
Sequence modifications
E: 1 - 826 (UniProt: Q9BQ52)
F: 40 - 403 (UniProt: Q7L0Y3)
| PDB | External Database | Details |
|---|---|---|
| Ala 548 | His 548 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met 18 | - | initiating methionine |
| His 19 | - | expression tag |
| His 20 | - | expression tag |
| His 21 | - | expression tag |
| His 22 | - | expression tag |
| His 23 | - | expression tag |
| His 24 | - | expression tag |
| Ser 25 | - | expression tag |
| Ser 26 | - | expression tag |
| Gly 27 | - | expression tag |
| Val 28 | - | expression tag |
| Asp 29 | - | expression tag |
| Leu 30 | - | expression tag |
| Gly 31 | - | expression tag |
| Thr 32 | - | expression tag |
| Glu 33 | - | expression tag |
| Asn 34 | - | expression tag |
| Leu 35 | - | expression tag |
| Tyr 36 | - | expression tag |
| Phe 37 | - | expression tag |
| Gln 38 | - | expression tag |
| Ser 39 | - | expression tag |
| Ala 404 | - | expression tag |
| Glu 405 | - | expression tag |
| Asn 406 | - | expression tag |
| Leu 407 | - | expression tag |
| Tyr 408 | - | expression tag |
| Phe 409 | - | expression tag |
| Gln 410 | - | expression tag |
| Ser 411 | - | expression tag |
| His 412 | - | expression tag |
| His 413 | - | expression tag |
| His 414 | - | expression tag |
| His 415 | - | expression tag |
| His 416 | - | expression tag |
| His 417 | - | expression tag |
| Asp 418 | - | expression tag |
| Tyr 419 | - | expression tag |
| Lys 420 | - | expression tag |
| Asp 421 | - | expression tag |
| Asp 422 | - | expression tag |
| Asp 423 | - | expression tag |
| Asp 424 | - | expression tag |
| Lys 425 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 288944.2 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 3103.5 | |
| All* | Total formula weight | 292047.7 |
