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8CB6

Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in covalent complex with TAMRA tagged 1,6-Epi-cylcophellitol aziridine activity based probe

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(F)
Lysosomal alpha-glucosidase (76 kDa)polymer12314095.01UniProt (P10253)
Pfam (PF00088)
Homo sapiens (human)
2B
(A)
Lysosomal alpha-glucosidase (70 kDa)polymer74982901.61UniProt (P10253)
Pfam (PF13802)
Pfam (PF01055)
Pfam (PF21365)
Homo sapiens (human)
3C
(B)
2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranosebranched570.51In PDB
GlyTouCan (G21290RB)
4D, E
(C, D)
2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched424.42In PDB
GlyTouCan (G42666HT)
5F
(E)
beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched586.51In PDB
GlyTouCan (G15407YE)
6G, H, I, T, U...
(F, A)
CHLORIDE IONnon-polymer35.510Chemie (CL)
7AA, BA, CA, EA, HA...
(A, F)
1,2-ETHANEDIOLnon-polymer62.110Chemie (EDO)
8DA, FA, GA, K
(A, F)
GLYCEROLnon-polymer92.14Chemie (GOL)
9N
(A)
(1S,2R,3R,4R,5R)-5-[8-[4-(4-azanylbutyl)-1,2,3-triazol-1-yl]octylamino]-4-(hydroxymethyl)cyclohexane-1,2,3-triolnon-polymer427.61Chemie (U54)
10O
(A)
2-acetamido-2-deoxy-beta-D-glucopyranosenon-polymer221.21Chemie (NAG)
11P, Q, R, S
(A)
SULFATE IONnon-polymer96.14Chemie (SO4)
12KA
(A)
TRIETHYLENE GLYCOLnon-polymer150.21Chemie (PGE)
13LA, MA
(F, A)
waterwater18.0612Chemie (HOH)
Sequence modifications
F: 81 - 203 (UniProt: P10253)
PDBExternal DatabaseDetails
Arg 199His 199conflict
A: 204 - 952 (UniProt: P10253)
PDBExternal DatabaseDetails
His 223Arg 223conflict
Ile 780Val 780conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight96996.6
BranchedNumber of molecules4
Total formula weight2005.9
Non-Polymers*Number of molecules31
Total formula weight2526.8
All*Total formula weight101529.3
*Water molecules are not included.

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PDB entries from 2024-10-30

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