8CA8
Crystal structure of SARS-CoV-2 Mpro-H172Y mutant, free enzyme
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (AAA) | 3C-like proteinase nsp5 | polymer | 302 | 33375.0 | 1 | UniProt (P0DTC1) Pfam (PF05409) UniProt (by SIFTS) (P0DTD1) | Severe acute respiratory syndrome coronavirus 2 | 3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase |
| 2 | B (AAA) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 3 | C (AAA) | water | water | 18.0 | 64 | Chemie (HOH) |
Sequence modifications
AAA: 1 - 302 (UniProt: P0DTC1)
| PDB | External Database | Details |
|---|---|---|
| Glu 92 | Asp 3355 | conflict |
| Val 136 | Ile 3399 | conflict |
| Tyr 172 | His 3435 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33375.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 35.5 | |
| All* | Total formula weight | 33410.5 |
