8CA3
Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 2).
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | NADH-ubiquinone oxidoreductase chain 3 | polymer | 115 | 13251.8 | 1 | UniProt (P03899) Pfam (PF00507) In PDB | Mus musculus (house mouse) | NADH dehydrogenase subunit 3 |
| 2 | B | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial | polymer | 224 | 24715.9 | 1 | UniProt (Q9DC70) Pfam (PF01058) In PDB | Mus musculus (house mouse) | Complex I-20kD,CI-20kD,NADH-ubiquinone oxidoreductase 20 kDa subunit |
| 3 | C | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial | polymer | 263 | 30191.3 | 1 | UniProt (Q9DCT2) Pfam (PF00329) In PDB | Mus musculus (house mouse) | Complex I-30kD,CI-30kD,NADH-ubiquinone oxidoreductase 30 kDa subunit |
| 4 | D | NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial | polymer | 463 | 52720.6 | 1 | UniProt (Q91WD5) Pfam (PF00346) In PDB | Mus musculus (house mouse) | Complex I-49kD,CI-49kD,NADH-ubiquinone oxidoreductase 49 kDa subunit |
| 5 | E | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial | polymer | 245 | 27077.0 | 1 | UniProt (Q9D6J6) Pfam (PF01257) In PDB | Mus musculus (house mouse) | NADH-ubiquinone oxidoreductase 24 kDa subunit |
| 6 | F | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | polymer | 464 | 50904.2 | 1 | UniProt (Q91YT0) Pfam (PF01512) Pfam (PF10589) In PDB | Mus musculus (house mouse) | Complex I-51kD,CI-51kD,NADH-ubiquinone oxidoreductase 51 kDa subunit |
| 7 | G | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial | polymer | 727 | 79866.7 | 1 | UniProt (Q91VD9) Pfam (PF00384) Pfam (PF09326) Pfam (PF13510) Pfam (PF10588) In PDB | Mus musculus (house mouse) | Complex I-75kD,CI-75kD |
| 8 | H | NADH-ubiquinone oxidoreductase chain 1 | polymer | 318 | 36105.0 | 1 | UniProt (P03888) Pfam (PF00146) In PDB | Mus musculus (house mouse) | NADH dehydrogenase subunit 1 |
| 9 | I | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial | polymer | 212 | 24068.4 | 1 | UniProt (Q8K3J1) Pfam (PF12838) In PDB | Mus musculus (house mouse) | Complex I-23kD,CI-23kD,NADH-ubiquinone oxidoreductase 23 kDa subunit |
| 10 | J | NADH-ubiquinone oxidoreductase chain 6 | polymer | 172 | 18656.1 | 1 | UniProt (P03925) Pfam (PF00499) In PDB | Mus musculus (house mouse) | NADH dehydrogenase subunit 6 |
| 11 | K | NADH-ubiquinone oxidoreductase chain 4L | polymer | 98 | 10637.6 | 1 | UniProt (P03903) Pfam (PF00420) In PDB | Mus musculus (house mouse) | NADH dehydrogenase subunit 4L |
| 12 | L | NADH-ubiquinone oxidoreductase chain 5 | polymer | 607 | 68547.3 | 1 | UniProt (P03921) Pfam (PF00662) Pfam (PF00361) Pfam (PF06455) In PDB | Mus musculus (house mouse) | NADH dehydrogenase subunit 5 |
| 13 | M | NADH-ubiquinone oxidoreductase chain 4 | polymer | 459 | 51943.5 | 1 | UniProt (P03911) Pfam (PF01059) Pfam (PF00361) In PDB | Mus musculus (house mouse) | NADH dehydrogenase subunit 4 |
| 14 | N | NADH-ubiquinone oxidoreductase chain 2 | polymer | 345 | 38800.2 | 1 | UniProt (P03893) Pfam (PF00361) Pfam (PF06444) In PDB | Mus musculus (house mouse) | NADH dehydrogenase subunit 2 |
| 15 | O | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial | polymer | 355 | 40657.4 | 1 | UniProt (Q99LC3) Pfam (PF01712) In PDB | Mus musculus (house mouse) | Complex I-42kD,CI-42kD,NADH-ubiquinone oxidoreductase 42 kDa subunit |
| 16 | P | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial | polymer | 377 | 42588.1 | 1 | UniProt (Q9DC69) Pfam (PF05368) In PDB | Mus musculus (house mouse) | Complex I-39kD,CI-39kD,NADH-ubiquinone oxidoreductase 39 kDa subunit |
| 17 | R | NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial | polymer | 116 | 13041.8 | 1 | UniProt (P52503) Pfam (PF10276) In PDB | Mus musculus (house mouse) | Complex I-13kD-A,CI-13kD-A,NADH-ubiquinone oxidoreductase 13 kDa-A subunit |
| 18 | S | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 | polymer | 99 | 10932.7 | 1 | UniProt (Q9CQ75) Pfam (PF05047) In PDB | Mus musculus (house mouse) | Complex I-B8,CI-B8,NADH-ubiquinone oxidoreductase B8 subunit |
| 19 | T, U | Acyl carrier protein, mitochondrial | polymer | 156 | 17390.3 | 2 | UniProt (Q9CR21) Pfam (PF00550) In PDB | Mus musculus (house mouse) | ACP,CI-SDAP,NADH-ubiquinone oxidoreductase 9.6 kDa subunit |
| 20 | V | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | polymer | 116 | 13380.7 | 1 | UniProt (Q9CPP6) Pfam (PF04716) In PDB | Mus musculus (house mouse) | Complex I subunit B13,Complex I-13kD-B,CI-13kD-B,NADH-ubiquinone oxidoreductase 13 kDa-B subunit |
| 21 | W | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 | polymer | 131 | 15311.9 | 1 | UniProt (Q9CQZ5) Pfam (PF13233) In PDB | Mus musculus (house mouse) | Complex I-B14,CI-B14,NADH-ubiquinone oxidoreductase B14 subunit |
| 22 | X | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 | polymer | 172 | 20025.1 | 1 | UniProt (Q9DCJ5) Pfam (PF06747) In PDB | Mus musculus (house mouse) | Complex I-19kD,CI-19kD,Complex I-PGIV,CI-PGIV,NADH-ubiquinone oxidoreductase 19 kDa subunit |
| 23 | Y | MCG5603 | polymer | 143 | 15130.4 | 1 | UniProt (G5E814) Pfam (PF02466) In PDB | Mus musculus (house mouse) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 |
| 24 | Z | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 | polymer | 144 | 16881.6 | 1 | UniProt (Q9ERS2) Pfam (PF06212) In PDB | Mus musculus (house mouse) | Cell death regulatory protein GRIM-19,Complex I-B16.6,CI-B16.6,Gene associated with retinoic and interferon-induced mortality 19 protein,Gene associated with retinoic and IFN-induced mortality 19 protein,NADH-ubiquinone oxidoreductase B16.6 subunit |
| 25 | a | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | polymer | 70 | 8149.5 | 1 | UniProt (O35683) Pfam (PF15879) In PDB | Mus musculus (house mouse) | Complex I-MWFE,CI-MWFE,NADH-ubiquinone oxidoreductase MWFE subunit |
| 26 | b | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 | polymer | 84 | 9338.9 | 1 | UniProt (Q9CQ91) Pfam (PF14987) In PDB | Mus musculus (house mouse) | Complex I-B9,CI-B9,NADH-ubiquinone oxidoreductase B9 subunit |
| 27 | c | NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial | polymer | 76 | 8636.0 | 1 | UniProt (Q9CQY9) Pfam (PF15088) In PDB | Mus musculus (house mouse) | Complex I-KFYI,CI-KFYI,NADH-ubiquinone oxidoreductase KFYI subunit |
| 28 | d | NADH dehydrogenase [ubiquinone] 1 subunit C2 | polymer | 120 | 14185.7 | 1 | UniProt (Q9CQ54) Pfam (PF06374) In PDB | Mus musculus (house mouse) | Complex I-B14.5b,CI-B14.5b,NADH-ubiquinone oxidoreductase subunit B14.5b |
| 29 | e | NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 | polymer | 106 | 12675.8 | 1 | UniProt (Q99LY9) Pfam (PF10200) In PDB | Mus musculus (house mouse) | Complex I-15 kDa,CI-15 kDa,NADH-ubiquinone oxidoreductase 15 kDa subunit |
| 30 | f | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 | polymer | 57 | 6965.1 | 1 | UniProt (P0DN34) Pfam (PF08040) In PDB | Mus musculus (house mouse) | Complex I-MNLL,CI-MNLL,NADH-ubiquinone oxidoreductase MNLL subunit |
| 31 | g | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial | polymer | 151 | 17463.7 | 1 | UniProt (O09111) Pfam (PF10183) In PDB | Mus musculus (house mouse) | Complex I-ESSS,CI-ESSS,NADH-ubiquinone oxidoreductase ESSS subunit,Neuronal protein 15.6,p15.6 |
| 32 | h | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial | polymer | 189 | 21742.2 | 1 | UniProt (Q9CQH3) Pfam (PF09781) In PDB | Mus musculus (house mouse) | Complex I-SGDH,CI-SGDH,NADH-ubiquinone oxidoreductase SGDH subunit |
| 33 | i | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 | polymer | 127 | 15450.9 | 1 | UniProt (Q3UIU2) Pfam (PF09782) In PDB | Mus musculus (house mouse) | Complex I-B17,CI-B17,NADH-ubiquinone oxidoreductase B17 subunit |
| 34 | j | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial | polymer | 105 | 11982.4 | 1 | UniProt (Q9CPU2) Pfam (PF14813) In PDB | Mus musculus (house mouse) | Complex I-AGGG,CI-AGGG,NADH-ubiquinone oxidoreductase AGGG subunit |
| 35 | k | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 | polymer | 104 | 11714.2 | 1 | UniProt (Q9CQZ6) Pfam (PF08122) In PDB | Mus musculus (house mouse) | Complex I-B12,CI-B12,NADH-ubiquinone oxidoreductase B12 subunit |
| 36 | l | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial | polymer | 186 | 21903.8 | 1 | UniProt (Q9D6J5) Pfam (PF05821) In PDB | Mus musculus (house mouse) | Complex I-ASHI,CI-ASHI,NADH-ubiquinone oxidoreductase ASHI subunit |
| 37 | m | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 | polymer | 129 | 15105.3 | 1 | UniProt (Q9CQC7) Pfam (PF07225) In PDB | Mus musculus (house mouse) | Complex I-B15,CI-B15,NADH-ubiquinone oxidoreductase B15 subunit |
| 38 | n | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 | polymer | 179 | 22020.1 | 1 | UniProt (Q9CQJ8) Pfam (PF05347) In PDB | Mus musculus (house mouse) | Complex I-B22,CI-B22,NADH-ubiquinone oxidoreductase B22 subunit |
| 39 | o | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 | polymer | 137 | 16360.8 | 1 | UniProt (Q9CR61) Pfam (PF05676) In PDB | Mus musculus (house mouse) | Complex I-B18,CI-B18,NADH-ubiquinone oxidoreductase B18 subunit |
| 40 | p | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 | polymer | 176 | 21054.8 | 1 | UniProt (Q9DCS9) Pfam (PF10249) In PDB | Mus musculus (house mouse) | Complex I-PDSW,CI-PDSW,NADH-ubiquinone oxidoreductase PDSW subunit |
| 41 | r | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 | polymer | 113 | 12595.6 | 1 | UniProt (Q9Z1P6) Pfam (PF07347) In PDB | Mus musculus (house mouse) | Complex I-B14.5a,CI-B14.5a,NADH-ubiquinone oxidoreductase subunit B14.5a |
| 42 | s | NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial | polymer | 104 | 11833.5 | 1 | UniProt (Q8BK30) Pfam (PF15880) In PDB | Mus musculus (house mouse) | Complex I-9kD,CI-9kD,NADH-ubiquinone oxidoreductase 9 kDa subunit |
| 43 | I, B, F, G | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 6 | Chemie (SF4) | |||
| 44 | H, B | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 790.1 | 2 | Chemie (PC1) | |||
| 45 | E, G | FE2/S2 (INORGANIC) CLUSTER | non-polymer | 175.8 | 2 | Chemie (FES) | |||
| 46 | F | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) | |||
| 47 | H | Ubiquinone-9 | non-polymer | 795.2 | 1 | Chemie (UQ9) | |||
| 48 | H, J, L, Y, Z... | 1,2-Distearoyl-sn-glycerophosphoethanolamine | non-polymer | 748.1 | 7 | Chemie (3PE) | |||
| 49 | L, M, N, d, h | CARDIOLIPIN | non-polymer | 1464.0 | 6 | Chemie (CDL) | |||
| 50 | L | DODECYL-BETA-D-MALTOSIDE | non-polymer | 510.6 | 2 | Chemie (LMT) | |||
| 51 | O | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) | |||
| 52 | P | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
| 53 | R | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 54 | T, U | ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate | non-polymer | 584.7 | 2 | Chemie (EHZ) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 43 |
| Total formula weight | 1009394.5 | |
| Non-Polymers* | Number of molecules | 32 |
| Total formula weight | 22838.7 | |
| All* | Total formula weight | 1032233.2 |
