8C8W
Priestia megaterium mupirocin hyper-resistant HIGH motif mutant of type 2 isoleucyl-tRNA synthetase complexed with an isoleucyl-adenylate analogue
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Isoleucine--tRNA ligase | polymer | 1032 | 117863.8 | 1 | UniProt (A0A0B6AVD3) Pfam (PF00133) Pfam (PF08264) Pfam (PF19302) | Priestia megaterium | Isoleucyl-tRNA synthetase,IleRS |
| 2 | B (A) | N-[ISOLEUCINYL]-N'-[ADENOSYL]-DIAMINOSUFONE | non-polymer | 458.5 | 1 | Chemie (ILA) | |||
| 3 | C, F, G, H (A) | D(-)-TARTARIC ACID | non-polymer | 150.1 | 4 | Chemie (TAR) | |||
| 4 | D, E (A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | I (A) | water | water | 18.0 | 260 | Chemie (HOH) |
Sequence modifications
A: 1 - 1032 (UniProt: A0A0B6AVD3)
| PDB | External Database | Details |
|---|---|---|
| Gly 54 | His 54 | engineered mutation |
| His 56 | Gly 56 | engineered mutation |
| Ala 109 | Lys 109 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 117863.8 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1189.7 | |
| All* | Total formula weight | 119053.5 |
