8C7R
Crystal structure of rat autotaxin and compound MEY-003
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | polymer | 862 | 98826.3 | 1 | UniProt (Q64610) Pfam (PF01033) Pfam (PF01663) Pfam (PF01223) In PDB | Rattus norvegicus (Norway rat) | E-NPP 2,Autotaxin,Extracellular lysophospholipase D,LysoPLD |
2 | B | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
3 | A | 5,7-bis(oxidanyl)-2-(1-pentylindol-3-yl)chromen-4-one | non-polymer | 363.4 | 1 | Chemie (T8R) | |||
4 | A | 7alpha-hydroxycholesterol | non-polymer | 402.7 | 1 | Chemie (5JK) | |||
5 | A | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
6 | A | IODIDE ION | non-polymer | 126.9 | 4 | Chemie (IOD) | |||
7 | A | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
8 | water | water | 18.0 | 94 | Chemie (HOH) |
Sequence modifications
A: 1 - 862 (UniProt: Q64610)
PDB | External Database | Details |
---|---|---|
Ala 53 | Asn 53 | engineered mutation |
Ala 410 | Asn 410 | engineered mutation |
- | Glu 592 | deletion |
- | Ala 593 | deletion |
- | Glu 594 | deletion |
- | Thr 595 | deletion |
- | Gly 596 | deletion |
- | Lys 597 | deletion |
- | Phe 598 | deletion |
- | Arg 599 | deletion |
- | Gly 600 | deletion |
- | Ser 601 | deletion |
- | Lys 602 | deletion |
- | His 603 | deletion |
- | Glu 604 | deletion |
- | Asn 605 | deletion |
- | Lys 606 | deletion |
- | Lys 607 | deletion |
- | Asn 608 | deletion |
- | Leu 609 | deletion |
- | Asn 610 | deletion |
- | Gly 611 | deletion |
- | Ser 612 | deletion |
- | Val 613 | deletion |
- | Glu 614 | deletion |
- | Pro 615 | deletion |
- | Arg 616 | deletion |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 98826.3 | |
Branched | Number of molecules | 1 |
Total formula weight | 424.4 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 1484.6 | |
All* | Total formula weight | 100735.3 |