8C44

HB3VAR03 apo headstructure (PfEMP1 A) complexed with EPCR

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	PfEMP1	polymer	1259	145158.8	1	UniProt (A0A0L7KL67) Pfam (PF15447) Pfam (PF05424) Pfam (PF22672) Pfam (PF21807) Pfam (PF03011)	Plasmodium falciparum HB3
2	B (C)	Endothelial protein C receptor	polymer	168	19471.9	1	UniProt (Q9UNN8) Pfam (PF16497)	Homo sapiens (human)	Activated protein C receptor,APC receptor,Endothelial cell protein C receptor
3	C (C)	PHOSPHATIDYLETHANOLAMINE	non-polymer		734.0	1	Chemie (PTY)
4	D (C)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)

Sequence modifications

A: 1 - 1234 (UniProt: A0A0L7KL67)

PDB	External Database	Details
Ala 2	Gly 2	conflict
Thr 531	Asn 531	conflict
Ile 534	Gly 534	conflict
Asn 535	Lys 535	conflict
Val 568	Ile 568	conflict
Lys 602	Val 602	conflict
Phe 603	Thr 603	conflict
Trp 604	Asp 604	conflict
Gly 1235	-	expression tag
Gly 1236	-	expression tag
Ser 1237	-	expression tag
His 1238	-	expression tag
His 1239	-	expression tag
His 1240	-	expression tag
His 1241	-	expression tag
His 1242	-	expression tag
His 1243	-	expression tag
Gly 1244	-	expression tag
Gly 1245	-	expression tag
Gly 1246	-	expression tag
Ser 1247	-	expression tag
Ala 1248	-	expression tag
His 1249	-	expression tag
Ile 1250	-	expression tag
Val 1251	-	expression tag
Val 1252	-	expression tag
Asp 1253	-	expression tag
Ala 1254	-	expression tag
Tyr 1255	-	expression tag
Lys 1256	-	expression tag
Pro 1257	-	expression tag
Thr 1258	-	expression tag
Lys 1259	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	164630.7
Non-Polymers*	Number of molecules	2
	Total formula weight	955.2
All*	Total formula weight	165585.9

*Water molecules are not included.