8C3Q

Crystal structure of DYRK1A in complex with rutin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	polymer	370	43180.6	2	UniProt (Q13627) Pfam (PF00069)	Homo sapiens (human)	Dual specificity YAK1-related kinase,HP86,Protein kinase minibrain homolog,MNBH,hMNB
2	C, D (A, B)	RUTIN	non-polymer		610.5	2	Chemie (RUT)
3	E, F (A, B)	water	water		18.0	190	Chemie (HOH)

Sequence modifications

A, B: 126 - 489 (UniProt: Q13627)

PDB	External Database	Details
His 490	-	expression tag
His 491	-	expression tag
His 492	-	expression tag
His 493	-	expression tag
His 494	-	expression tag
His 495	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	86361.1
Non-Polymers*	Number of molecules	2
	Total formula weight	1221.0
All*	Total formula weight	87582.2

*Water molecules are not included.