8C1M
Aurora A kinase in complex with TPX2-inhibitor 2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Aurora kinase A | polymer | 273 | 31664.3 | 1 | UniProt (O14965) Pfam (PF00069) In PDB | Homo sapiens (human) | Aurora 2,Aurora/IPL1-related kinase 1,ARK-1,Aurora-related kinase 1,Breast tumor-amplified kinase,Ipl1- and aurora-related kinase 1,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase Ayk1,Serine/threonine-protein kinase aurora-A |
| 2 | A | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 3 | A | 3-oxidanyl-5-[4-(trifluoromethyloxy)phenyl]benzoic acid | non-polymer | 298.2 | 1 | Chemie (T4X) | |||
| 4 | A | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) |
Sequence modifications
A: 125 - 391 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Gln 119 | - | expression tag |
| Gly 120 | - | expression tag |
| Ser 121 | - | expression tag |
| Met 122 | - | expression tag |
| Gly 123 | - | expression tag |
| Ser 124 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31664.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 774.0 | |
| All* | Total formula weight | 32438.3 |
