8C1K
Aurora A kinase in complex with TPX2-inhibitor CAM2602
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Aurora kinase A | polymer | 273 | 31805.5 | 1 | UniProt (O14965) Pfam (PF00069) In PDB | Homo sapiens (human) | Aurora 2,Aurora/IPL1-related kinase 1,ARK-1,Aurora-related kinase 1,Breast tumor-amplified kinase,Ipl1- and aurora-related kinase 1,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase Ayk1,Serine/threonine-protein kinase aurora-A |
2 | A | 4-(4-chloranyl-3-pyridin-2-yloxy-phenyl)-~{N}-(dimethylsulfamoyl)-7-methyl-1~{H}-indole-6-carboxamide | non-polymer | 485.0 | 1 | Chemie (T4O) | |||
3 | A | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
4 | A | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
5 | A | (1~{R},2~{R})-cyclohexane-1,2-dicarboxylic acid | non-polymer | 172.2 | 1 | Chemie (T5L) | |||
6 | A | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
7 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 3 | Chemie (DMS) | |||
8 | A | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
9 | water | water | 18.0 | 39 | Chemie (HOH) |
Sequence modifications
A: 126 - 390 (UniProt: O14965)
PDB | External Database | Details |
---|---|---|
Met 124 | - | initiating methionine |
Gly 125 | - | expression tag |
Ala 290 | Cys 290 | engineered mutation |
His 391 | - | expression tag |
His 392 | - | expression tag |
His 393 | - | expression tag |
His 394 | - | expression tag |
His 395 | - | expression tag |
His 396 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 31805.5 | |
Non-Polymers* | Number of molecules | 14 |
Total formula weight | 1906.7 | |
All* | Total formula weight | 33712.2 |