8C1F
Aurora A kinase in complex with TPX2-inhibitor 6
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Aurora kinase A | polymer | 265 | 30750.3 | 1 | UniProt (O14965) Pfam (PF00069) | Homo sapiens (human) | Aurora 2,Aurora/IPL1-related kinase 1,ARK-1,Aurora-related kinase 1,Breast tumor-amplified kinase,Ipl1- and aurora-related kinase 1,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase Ayk1,Serine/threonine-protein kinase aurora-A |
| 2 | B (A) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 3 | C, D (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | E, F, G, H, I (A) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 5 | J (A) | (1~{R},2~{R})-cyclohexane-1,2-dicarboxylic acid | non-polymer | 172.2 | 1 | Chemie (T5L) | |||
| 6 | K, L, M, N, O... (A) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 7 | Q (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 8 | R (A) | 4-(4-chlorophenyl)-~{N}-cyclopropylsulfonyl-7-methyl-1~{H}-indole-6-carboxamide | non-polymer | 388.9 | 1 | Chemie (T2O) | |||
| 9 | S (A) | water | water | 18.0 | 90 | Chemie (HOH) |
Sequence modifications
A: 126 - 388 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Met 124 | - | initiating methionine |
| Gly 125 | - | expression tag |
| Ala 290 | Cys 290 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 30750.3 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 2151.8 | |
| All* | Total formula weight | 32902.2 |
