8C14
Aurora A kinase in complex with TPX2-inhibitor 9
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Aurora kinase A | polymer | 272 | 31536.1 | 1 | UniProt (O14965) Pfam (PF00069) | Homo sapiens (human) | Aurora 2,Aurora/IPL1-related kinase 1,hARK1,Breast tumor-amplified kinase,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase aurora-A |
| 2 | B, C, D (A) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 3 | E (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | F, G, H, I, J... (A) | CHLORIDE ION | non-polymer | 35.5 | 6 | Chemie (CL) | |||
| 5 | L, M, N, O (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 4 | Chemie (DMS) | |||
| 6 | P, Q (A) | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
| 7 | R (A) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 8 | S (A) | (1~{R},2~{R})-cyclohexane-1,2-dicarboxylic acid | non-polymer | 172.2 | 1 | Chemie (T5L) | |||
| 9 | T, U, V, W, X (A) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 10 | Y (A) | 4-(4-chloranyl-3-cyano-phenyl)-1~{H}-indole-6-carboxylic acid | non-polymer | 296.7 | 1 | Chemie (T0L) | |||
| 11 | Z (A) | water | water | 18.0 | 205 | Chemie (HOH) |
Sequence modifications
A: 125 - 391 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Gly 120 | - | expression tag |
| Ser 121 | - | expression tag |
| Met 122 | - | expression tag |
| Gly 123 | - | expression tag |
| Ser 124 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31536.1 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 2168.9 | |
| All* | Total formula weight | 33705.0 |
