8C09

Crystal structure of JAK2 JH2-I559F

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Tyrosine-protein kinase JAK2	polymer	289	33155.0	1	UniProt (O60674) Pfam (PF07714) In PDB	Homo sapiens (human)	Janus kinase 2,JAK-2
2		water	water		18.0	108	Chemie (HOH)

Sequence modifications

A: 536 - 812 (UniProt: O60674)

PDB	External Database	Details
Phe 559	Ile 559	engineered mutation
Ala 659	Trp 659	engineered mutation
Ala 777	Trp 777	engineered mutation
His 794	Phe 794	engineered mutation
Leu 813	-	expression tag
Val 814	-	expression tag
Pro 815	-	expression tag
Arg 816	-	expression tag
Gly 817	-	expression tag
Ser 818	-	expression tag
His 819	-	expression tag
His 820	-	expression tag
His 821	-	expression tag
His 822	-	expression tag
His 823	-	expression tag
His 824	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	33155.0
All*	Total formula weight	33155.0

*Water molecules are not included.