8C08
Crystal structure of JAK2 JH2-K539L
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Tyrosine-protein kinase JAK2 | polymer | 289 | 33104.9 | 2 | UniProt (O60674) Pfam (PF07714) In PDB | Homo sapiens (human) | Janus kinase 2,JAK-2 |
2 | A, B | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
3 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
4 | B | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
5 | water | water | 18.0 | 82 | Chemie (HOH) |
Sequence modifications
A, B: 536 - 812 (UniProt: O60674)
PDB | External Database | Details |
---|---|---|
Leu 539 | Lys 539 | variant |
Ala 659 | Trp 659 | engineered mutation |
Ala 777 | Trp 777 | engineered mutation |
His 794 | Phe 794 | engineered mutation |
Leu 813 | - | expression tag |
Val 814 | - | expression tag |
Pro 815 | - | expression tag |
Arg 816 | - | expression tag |
Gly 817 | - | expression tag |
Ser 818 | - | expression tag |
His 819 | - | expression tag |
His 820 | - | expression tag |
His 821 | - | expression tag |
His 822 | - | expression tag |
His 823 | - | expression tag |
His 824 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 66209.9 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 1155.1 | |
All* | Total formula weight | 67364.9 |