8BZY
Structure of SLC40/ferroportin in complex with vamifeport and synthetic nanobody Sy3 in occluded conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Solute carrier family 40 member 1 | polymer | 580 | 63536.8 | 1 | UniProt (Q9NP59) Pfam (PF06963) | Homo sapiens (human) | Ferroportin-1,Iron-regulated transporter 1 |
| 2 | B (B) | Sybody 3 | polymer | 146 | 16343.1 | 1 | synthetic construct | ||
| 3 | C (A) | DIUNDECYL PHOSPHATIDYL CHOLINE | non-polymer | 622.8 | 1 | Chemie (PLC) | |||
| 4 | D (A) | 2-[2-[2-(1~{H}-benzimidazol-2-yl)ethylamino]ethyl]-~{N}-[(3-fluoranylpyridin-2-yl)methyl]-1,3-oxazole-4-carboxamide | non-polymer | 408.4 | 1 | Chemie (SZU) |
Sequence modifications
A: 2 - 571 (UniProt: Q9NP59)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| Ser 1 | - | expression tag |
| Ala 572 | - | expression tag |
| Leu 573 | - | expression tag |
| Glu 574 | - | expression tag |
| Val 575 | - | expression tag |
| Leu 576 | - | expression tag |
| Phe 577 | - | expression tag |
| Gln 578 | - | expression tag |
| Gly 579 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 79880.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1031.3 | |
| All* | Total formula weight | 80911.2 |
