8BZW
Co-soaked stabilizers for ERa - 14-3-3 interaction (844_AZ210)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | 14-3-3 protein sigma | polymer | 236 | 26542.9 | 1 | UniProt (P31947) Pfam (PF00244) In PDB | Homo sapiens (human) | Epithelial cell marker protein 1,Stratifin |
| 2 | B | ERalpha peptide | polymer | 6 | 670.6 | 1 | UniProt (by SIFTS) (P03372) In PDB | Homo sapiens | |
| 3 | A | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 4 | A | 4-[(2~{R})-3-azanyl-2-methyl-propyl]-7-methoxy-1-benzothiophene-2-carboximidamide | non-polymer | 277.4 | 1 | Chemie (SSX) | |||
| 5 | A | 2-(4-chloranylphenoxy)-2-methyl-~{N}-(2-sulfanylethyl)propanamide | non-polymer | 273.8 | 1 | Chemie (GEH) | |||
| 6 | water | water | 18.0 | 345 | Chemie (HOH) |
Sequence modifications
A: 1 - 231 (UniProt: P31947)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Ala -3 | - | expression tag |
| Met -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Asn 38 | Cys 38 | engineered mutation |
| Cys 42 | Asn 42 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 27213.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 624.1 | |
| All* | Total formula weight | 27837.6 |
