8BZI
Human MST3 (STK24) kinase in complex with inhibitor MR39
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein kinase 24 | polymer | 306 | 34559.6 | 1 | UniProt (Q9Y6E0) Pfam (PF00069) | Homo sapiens (human) | Mammalian STE20-like protein kinase 3,MST-3,STE20-like kinase MST3 |
| 2 | B (A) | 8-(4-azanylbutyl)-6-[2,5-bis(fluoranyl)-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one | non-polymer | 450.5 | 1 | Chemie (SJL) | |||
| 3 | C, D, E (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 4 | F (A) | water | water | 18.0 | 221 | Chemie (HOH) |
Sequence modifications
A: 4 - 301 (UniProt: Q9Y6E0)
| PDB | External Database | Details |
|---|---|---|
| Met 3 | - | initiating methionine |
| Ala 302 | - | expression tag |
| His 303 | - | expression tag |
| His 304 | - | expression tag |
| His 305 | - | expression tag |
| His 306 | - | expression tag |
| His 307 | - | expression tag |
| His 308 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34559.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 636.7 | |
| All* | Total formula weight | 35196.3 |
